Unnatural Amino Acid
Home | Services & Solutions | Peptide | Discovery Synthesis | Unnatural Amino Acid
We are experts in producing a wide variety of unnatural amino acids (UAA), including the most challenging structures, tailored to our customers’ specifications within discovery scales.
Leveraging the knowledge and synthetic expertise of our seasoned chemists, we also offer custom amino acid synthesis services. If your desired structure is not on our list, or you require a bulk order, we are more than ready to assist. For custom synthesis inquiries, we can synthesize up to kilogram scales in our laboratory and up to ton scales at our dedicated plant. Additionally, we provide 2,500+ unnatural amino acid products.
Visit our UAA Catalog e-Shop here.
α-Me-amino acids:
- We employ the natural amino acid Alanine to design α-Me-amino acid derivatives. This methodology can be applied to other natural amino acids, such as Leucine, Phenylalanine, and so forth.
N-Me-amino acids:
- We have developed a cyclization process that forms the methylation in just two steps.
PG series:
- All protecting strategies, including Boc, Fmoc, Cbz, Mtt, DDE, and IVDDE, can be applied.
α- and β- construction series:
- We have developed enzyme catalyst techniques to construct selectable α- or β-site unnatural amino acids.
NCA series:
- We have developed a process to effectively control the quality of NCAs.
Case Study
- n=0,1,2…, m=1,2,3…
- Custom synthesis, from g to kg scale
- R1, R2, R3 can be different protecting groups upon your design
- Key building block for alternative route in cyclic peptide systhesis
- An alternative option for thioether macrocycles
- Commercial available in small quantity: 100 mg
- Commonly used for copper free click reaction
- Ideal building block for peptide fragment conjugation
- WuXi TIDES is capable of providing these analogs in 500+ grams scale with short timeline.
