Oligonucleotide Discovery Synthesis
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Our oligonucleotide drug discovery platform is equipped with experienced scientists and state-of-the-art facilities to support your discovery synthesis of oligonucleotides, complex conjugates, monomers, ligands and linkers, from sequence design to Pre-Clinical Candidiate (PCC).
We provide library synthesis, custom synthesis (nmol), and mid-scale synthesis (mmol). Our services cover all types of oligonucleotides with dedicated analytical support for all required testing.
Capability:
- siRNA, sgRNA, miRNA synthesis
- DNA, ASO, PMO & aptamer synthesis
- 2H / 13C / 15N labelled oligonucleotide synthesis
- Various sugar / backbone modified oligonucleotide synthesis
Experience Highlight:
- 50,000+ oligonucleotides per year
- Synthesize long oligonucleotides up to 158-nt
Library Synthesis (nmol - µmol)
- 192 channel synthesizers with up to 1 µmol set up for each column
- High purity by high throughput RP-HPLC or OPC™ (Oligonucleotide Purification Cartridge) purification
- Fast delivery: complete ~200 ds RNA within about 10 days
Custom Synthesis (µmol - mmol)
- Synthesizers up to 16 monomers selection enables highly modified oligonucleotide synthesis. (ÄKTA Oligo Pilot™ 10, ÄKTA OligoPilot™ 100)
- Expertise in long oligonucleotide synthesis for both ss RNA and ds RNA
- Experience with diverse challenging modified oligonucleotide synthesis such as ASO with all chiral phosphorothioates, RNA with 3'/5'-GalNAc, lipidation, PEGylation, etc.
Library Synthesis Experience Highlight
234 siRNA Duplexes
(200 nmol each)
144 5’-SMCC Aptamers
(375 nmol each)
206 PMOs
(300 nmol each)
40+ bp long & high-modified oligonucleotides (10 nmol each)
Case Study: From ‘Library’ Screening to Non-Human Primates Toxicological Development
- Broad Scale: integrated synthesis from 1 mg to 10 g
- High Speed: complete the whole project in 10 weeks
- Analytical support at all stages with method ready for later Tox study
Related Resources
WuXi TIDES Brochure: CRDMO Platform for Oligonucleotide, Peptide and Complex Conjugate
Oligonucleotide CRDMO Chemistry Platform
