Unnatural Amino Acid
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We are experts in producing a variety of unnatural amino acids including most challenging structures per our customers’ specifications from kilo to metric ton scale. With our global quality standard, we develop robust process of amino acid products with superior quality with cost effective control.
With the knowledge and synthetic skills of our experienced chemists , we also offer amino acid custom synthesis service. If your desired structure is not in this list, or you want a bulk order, we are happy to support. For custom synthesis inquiry, we can synthesize up to kg at laboratory, and ton scale at our dedicated plant, please send your requests to WuXi_TIDES@wuxiapptec.com, and we will respond shortly when we receive your custom synthesis inquiry.
α-Me-amino acids:
- Employ natural amino acid Alanine to design α-Me-amino acid derivatives. This type of methods can be applied to other natural amino acids (Leucine, Phenylalanine, etc.)
N-Me-amino acids:
- Develop the cyclization process to form the methylation by simply two steps
PG series:
- All protecting strategies (Boc, Fmoc, Cbz, Mtt, DDE, IVDDE) can be applied
α- and β- construction series:
- Develop enzyme catalyst techniques to construct selectable α- or β-site unnatural amino acids
NCA series:
- Develop the process to well control the quality of NCAs
Case Study
- n=0,1,2…, m=1,2,3…
- Custom synthesis, from g to kg scale
- R1, R2, R3 can be different protecting groups upon your design
- Key building block for alternative route in cyclic peptide construction
- An alternative option for thioether macrocycles
- Commercial available in small quantity: 100 mg, $400-$1000 market price
- Commonly used for copper free click reaction
- Ideal building block for peptide fragment conjugation
- WuXi is capable of providing these analogs in 500+ grams scale with short timeline and lower price
