WuXi TIDES has developed high loading solid-phase PMO synthesis process that can achieve >50% yield, >75% crude purity, >90% final product purity with <0.045 EU/mg endotoxin. Read more
Peptide Conjugate
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Peptide conjugate is a fast-growing area as a new modality for targeted drug delivery with improved efficacy and reduced side effects for cancer treatment. Our comprehensive peptide platform, coupled with our strong small molecule chemistry capability, provides a one-stop solution for peptide conjugate development and manufacturing. The peptide conjugates we support include but not limited to: PPMO, Oligonucleotide-Peptide, Peptide-Toxin.
- Design linkers with optimal size, suitable release mechanism and compatible conjugation chemistry
- Develop payload derivatives with modified toxicity and/or special linkage site
- Synthesize customized drug-linker complexes
- Seamless scale up from discovery to commercial
- Sample payload in stock: MMAE, MMAF, DM1, DM4, PBD, Doxorubicine derivatives etc
- Sample linkers in stock: MC-VC-PAB-PNP, Glu-VC-PAB, NHS-Glu-VC-PAB, Azido-Glu-VC-PAB, Hydrazone (acid Sensitive), Disulfide (Glutathione sensitive), SMCC etc
Samples of 350+ Linkers
Samples of 40+ Payload Modification
Integrated PDC development and manufacturing
Our integrated peptide-toxin development and manufacturing service saved 4-6 months
- Seamless collaboration with in-parallel activities across 4 workstreams
- Swift sample transport and information sharing from upstream to downstream teams
Peptide-Phosphorodiamidate Morpholino Oligomers (PMO)
As a type of oligonucleotide molecule, Phosphorodiamidate Morpholino Oligomers (PMO) are short single-stranded DNA analogs that are built upon a backbone of morpholine rings connected by phosphorodiamidate linkages. They are routinely used for gene silencing and the recently developed PMO-based drugs as excellent antisense reagents, however the synthesis of PMO remains challenging.
Related Resources
Webinar: Challenges and Opportunities in Peptide Drug Conjugates (PDCs)
Empowering Highly Potent Peptide Drug Conjugate Scale-up with Flow Chemistry
